This study shows that unbalanced excitation-inhibition neurotransmission in SMA mice impairs motor function, and reducing inhibition improves neuronal function and behavior.

Science Advances · Sep 5, 2025Peer-reviewedNeuroscience

Using CRISPR/Cas9 to identify genes required for mechanosensory neuron development and function

Christopher Jay Johnson, Akhil Kulkarni, William J. Buxton, Tsz Y. Hui, Anusha Kayastha, Alwin A. Khoja, Joviane Leandre, Vanshika V. Mehta, Logan Ostrowski, Erica G. Pareizs, Rebecca L. Scotto, Vanesa Vargas, Raveena M. Vellingiri, Giulia Verzino, Rhea Vohra, , Alberto Stolfi

The paper uses CRISPR/Cas9 in Ciona robusta to identify genes involved in mechanosensory neuron development and metamorphosis, finding Vamp1/2/3 as crucial for papillae function.

Biology Open · Aug 17, 2023Peer-reviewedDevelopmental Biology

Cancer Exacerbates Chemotherapy Induced Sensory Neuropathy

Stephen Nick Housley, Paul Nardelli, Darío I. Carrasco, Travis M. Rotterman, Emily Pfahl, Lilya V. Matyunina, John F. McDonald, Timothy C. Cope

The paper shows that chronic sensory neuropathy in rats results from non-linear interactions between cancer and chemotherapy, with Kv3.3 as a potential contributor.

Cancer Research · Apr 28, 2020Peer-reviewedNeuroscience

Sexually dimorphic responses to MPTP found in microglia, inflammation and gut microbiota in a progressive monkey model of Parkinson's disease

Valerie L. Joers, Gunasingh Jeyaraj Masilamoni, Doty Kempf, Alison R. Weiss, Travis M. Rotterman, Benjamin Murray, Gül Yalçın Çakmaklı, Ronald J. Voll, Mark M. Goodman, Leonard Lee Howell, Jocelyne Bachevalier, Stefan J. Green, Ankur D Naqib, Maliha W. Shaikh, Phillip A. Engen, , Malú G. Tansey

This study investigates sex differences in inflammatory responses and gut microbiota in a progressive monkey model of Parkinson's disease following MPTP treatment.

bioRxiv · Jan 30, 2020 · PreprintNeuroscience