Francisco J. Álvarez

The paper identifies corticospinal neuron subpopulations with opposing activity dynamics and shows they converge to shape spinal interneuron computations during skilled movement.

This study investigates how TREM2 in microglia influences neuronal degeneration and regeneration after axotomy, finding TREM2 promotes removal of degenerating motoneurons and supports regeneration of others.

This study shows that unbalanced excitation-inhibition neurotransmission in SMA mice impairs motor function, and reducing inhibition improves neuronal function and behavior.

This study shows that blocking GABA/glycine synaptic release on axotomized motoneurons slows motor axon regeneration and muscle reinnervation.

The paper identifies four V1 interneuron clades in the spinal cord based on birthdate, lineage, and connectivity, showing functional differences in their synaptic connections and circuit roles.