Structural insights into the mechanism of the human SGLT2-MAP17 glucose transporter
Masahiro Hiraizumi, Tomoya Akashi, Kouta Murasaki, Hiroyuki Kishida, Taichi Kumanomidou, Nao Torimoto, Osamu Nureki, Ikuko Miyaguchi
The paper determines the structures of the hSGLT2-MAP17 complex with SGLT2 inhibitors, revealing Na+-dependent transport mechanism and biphasic phlorizin binding.
bioRxiv · Jan 23, 2023 · PreprintMolecular Biology