Author

Tomoya Akashi

Tanabe Pharma Corporation (Japan)ORCID 0000-0002-2802-080XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Ikuko MiyaguchiiD· 2 shared Masahiro HiraizumiiD· 2 shared Osamu NurekiiD· 2 shared Taichi Kumanomidou· 2 shared Hidenori Todoroki· 1 shared Hidetsugu AsadaiD· 1 shared Hiromi Hisano· 1 shared Hiroyuki KishidaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPharmacology & Toxicology

Ikuko MiyaguchiORCID

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2 papers

Recent·Most cited

Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria

Takuya Imazu, Tomoya Akashi, Masahiro Hiraizumi, Yosuke Inui, Wataru Sasaki, Tsuyoshi Takahashi, Hidenori Todoroki, Taichi Kumanomidou, Kazunori D. Yamada, N. Fujikawa, Hiromi Hisano, Hidetsugu Asada, Tsukasa Kusakizako, Tomohiro Nishizawa, So Iwata, , Ikuko Miyaguchi

This study develops a potent B0AT1 inhibitor effective in a PKU mouse model by targeting an allosteric site.

Communications Biology · Jun 25, 2026Peer-reviewedPharmacology & Toxicology

Structural insights into the mechanism of the human SGLT2-MAP17 glucose transporter

Masahiro Hiraizumi, Tomoya Akashi, Kouta Murasaki, Hiroyuki Kishida, Taichi Kumanomidou, Nao Torimoto, Osamu Nureki, Ikuko Miyaguchi

The paper determines the structures of the hSGLT2-MAP17 complex with SGLT2 inhibitors, revealing Na+-dependent transport mechanism and biphasic phlorizin binding.

bioRxiv · Jan 23, 2023 · PreprintMolecular Biology