Author

Ikuko Miyaguchi

Tanabe Pharma Corporation (Japan)ORCID 0000-0003-0021-7296Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Kouta Murasaki· 2 shared Masahiro HiraizumiiD· 2 shared Osamu NurekiiD· 2 shared Taichi Kumanomidou· 2 shared Tomoya AkashiiD· 2 shared Akiko Kashima· 1 shared Hidenori Todoroki· 1 shared Hidetsugu AsadaiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Kouta Murasaki

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 20, 2026

Resolution-standardized evaluation of ligand atomic coordinates in crystallographic structures using machine learning

Ikuko Miyaguchi, Hiroaki Hata, Takaaki Kuribayashi…·Mitsunori Ikeguchi

The paper introduces aBCC, a machine learning-based metric for evaluating ligand coordinate-density consistency in crystallographic structures across different resolutions.

DOI 10.64898/2026.08.17.745351

protein structuremachine learning (classical)

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Pharmacology & ToxicologyCommunications BiologyPeer-reviewedJun 25, 2026

Structure-guided development of a potent human B0AT1 inhibitor effective in a mouse model of phenylketonuria

Takuya Imazu, Tomoya Akashi, Masahiro Hiraizumi…·Ikuko Miyaguchi

This study develops a potent B0AT1 inhibitor effective in a PKU mouse model by targeting an allosteric site.

1 citation

humanmouse

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Molecular BiologybioRxivPreprintJan 23, 2023

Structural insights into the mechanism of the human SGLT2-MAP17 glucose transporter

Masahiro Hiraizumi, Tomoya Akashi, Kouta Murasaki…·Ikuko Miyaguchi

The paper determines the structures of the hSGLT2-MAP17 complex with SGLT2 inhibitors, revealing Na+-dependent transport mechanism and biphasic phlorizin binding.

2 citations

humanexperimental assay

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