Mutagenic bypass of uracil-derived abasic sites underlies the SBS17 mutational signature
Stefania Di Ciccio, Joeri van Strien, Yang Jiang, Ammal Abbasi, Linda V. Bakker, Naomi Weertman, Laurynas Leiteris, Jeroen Willems, Ludmil B. Alexandrov, Juan I. Garaycoechea
This study identifies the mechanism of SBS17 mutational signature as misincorporation of dUTP during DNA replication and mutagenic bypass of abasic sites, applicable to both spontaneous and chemotherapy-induced mutations in gastrointestinal cancers.
bioRxiv · Aug 21, 2026 · PreprintMolecular Biology