Author

Jeroen Willems

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Juan I. GaraycoecheaiD· 3 shared Joeri van StrieniD· 2 shared Linda V. BakkeriD· 2 shared Yang JiangiD· 2 shared Abdulkadir AbakiriD· 1 shared Adrian Baez‐OrtegaiD· 1 shared Alexander E. E. Verkennis· 1 shared Ammal AbbasiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMolecular Biology

Juan I. GaraycoecheaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mutagenic bypass of uracil-derived abasic sites underlies the SBS17 mutational signature

Stefania Di Ciccio, Joeri van Strien, Yang Jiang, Ammal Abbasi, Linda V. Bakker, Naomi Weertman, Laurynas Leiteris, Jeroen Willems, Ludmil B. Alexandrov, Juan I. Garaycoechea

This study identifies the mechanism of SBS17 mutational signature as misincorporation of dUTP during DNA replication and mutagenic bypass of abasic sites, applicable to both spontaneous and chemotherapy-induced mutations in gastrointestinal cancers.

bioRxiv · Aug 21, 2026 · PreprintMolecular Biology

Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair

Yang Jiang, Moritz Jakob Przybilla, Linda V. Bakker, Foster C. Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E. E. Verkennis, Jamie T. Barnett, Adrian Baez‐Ortega, Federico Abascal, Peter W. Villalta, , Juan I. Garaycoechea

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

Nature Communications · Dec 12, 2025Peer-reviewedMolecular Biology

Primordial germ cell DNA demethylation and development require DNA translesion synthesis.

Pranay Shah, Ross J. Hill, Camille Dion, Stephen J. Clark, Abdulkadir Abakir, Jeroen Willems, Mark Johan Arends, Juan I. Garaycoechea, Harry G. Leitch, Wolf Reik, Gerry P. Crossan

The paper shows that DNA translesion synthesis is essential for primordial germ cell development and DNA demethylation in mammals, linking DDR to fertility.

Nature Communications · May 3, 2024Peer-reviewedDevelopmental Biology