Yang Jiang

Mutagenic bypass of uracil-derived abasic sites underlies the SBS17 mutational signature

This study identifies the mechanism of SBS17 mutational signature as misincorporation of dUTP during DNA replication and mutagenic bypass of abasic sites, applicable to both spontaneous and chemotherapy-induced mutations in gastrointestinal cancers.

Tissue-specific mutagenesis from endogenous guanine damageis suppressed by Polκ and DNA repair

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

Genome-wide mapping of 5'-aldehyde terminus induced by reactive oxygen species

The paper develops a method to map 5'-aldehyde termini in DNA at single-nucleotide resolution, revealing a preference for adenine bases and linking these lesions to genomic features and chromatin accessibility.