Juan I. Garaycoechea

The paper investigates the cellular consequences of exogenous 5hm-dC and endogenous oxidative demethylation, revealing distinct BER processes required for tolerance.

This study identifies the mechanism of SBS17 mutational signature as misincorporation of dUTP during DNA replication and mutagenic bypass of abasic sites, applicable to both spontaneous and chemotherapy-induced mutations in gastrointestinal cancers.

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

The paper shows that DNA translesion synthesis is essential for primordial germ cell development and DNA demethylation in mammals, linking DDR to fertility.