Joeri van Strien

This study identifies the mechanism of SBS17 mutational signature as misincorporation of dUTP during DNA replication and mutagenic bypass of abasic sites, applicable to both spontaneous and chemotherapy-induced mutations in gastrointestinal cancers.

The paper identifies endogenous guanine adducts as drivers of tissue-specific mutagenesis and shows that Polκ and DNA repair mechanisms suppress these mutations.

CompaCt integrates complexome profiling data across species to identify conserved and species-specific protein complexes and interactions, improving characterization through comparative analysis.

The paper identifies and validates a comprehensive list of mitochondrial proteins in Plasmodium falciparum using Bayesian statistics and experimental confirmation.

CEDAR provides a database for complexome profiling data with standardized formats, a web interface, and tools for analysis and exploration.

COPAL aligns complexome profiles to identify changes in mitochondrial protein complex abundance caused by Barth syndrome mutations.