Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa
This study identifies key residues in APETx1 and hERG that mediate inhibition by stabilizing the resting state of the hERG channel.
BMC Molecular and Cell Biology · Jan 7, 2021Peer-reviewedMolecular Biology