Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology
Rana Soylu-Kucharz, Natalie Adlesic, Marcus Davidsson, Tomas Björklund, Maria Björkqvist, Åsa Petersén
This study shows that mutant huntingtin in the hypothalamus causes ventral striatal neuropathology, including DARPP-32 neuron loss, and disrupts hypothalamus-ventral striatal circuitry in HD mice.
bioRxiv · Mar 4, 2023 · PreprintNeuroscience