Rana Soylu-Kucharz

Vascular dysfunction in Huntington's disease is located at the blood-CSF barrier and is rescued by sphingosine-1-phosphate receptor agonist

This study identifies vessel-type-specific vascular barrier dysfunction in Huntington's disease and shows partial rescue with an S1PR1 agonist.

Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology

This study shows that mutant huntingtin in the hypothalamus causes ventral striatal neuropathology, including DARPP-32 neuron loss, and disrupts hypothalamus-ventral striatal circuitry in HD mice.

Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models

The paper uses microarray analysis to identify gene expression changes in Huntington's disease mouse models, finding differential expression and pathway dysregulation associated with wild-type and mutant HTT overexpression.

IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model

This study shows that hypothalamic expression of mutant HTT causes sex-specific metabolic imbalance, and IKKβ inhibition reduces obesity in female HD mice.

Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

This study investigates whether excitotoxicity contributes to hypothalamic neuronal loss in HD mouse models, finding no evidence of excitotoxicity-induced damage in these models.

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis

This study shows that apoM-bound S1P regulates BBB permeability and transcytosis, with S1PR1 agonists able to restore permeability in apoM-deficient mice.