Maria Björkqvist

This study identifies vessel-type-specific vascular barrier dysfunction in Huntington's disease and shows partial rescue with an S1PR1 agonist.

This study shows that mutant huntingtin in the hypothalamus causes ventral striatal neuropathology, including DARPP-32 neuron loss, and disrupts hypothalamus-ventral striatal circuitry in HD mice.

The paper uses microarray analysis to identify gene expression changes in Huntington's disease mouse models, finding differential expression and pathway dysregulation associated with wild-type and mutant HTT overexpression.

This study investigates whether excitotoxicity contributes to hypothalamic neuronal loss in HD mouse models, finding no evidence of excitotoxicity-induced damage in these models.