Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of Plasmodium falciparum
Joseph W. Saelens, Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa S Konate, Seidina A. S. Diakité, Karim Traoré, Natalie Vance, Rick M. Fairhurst, Mahamadou Diakité, Steven B. Haase, Steve M. Taylor
This study identifies transcriptomic changes in Plasmodium falciparum in HbAS red blood cells, showing altered protein export and stress response mechanisms that may contribute to malaria protection.
mSphere · Oct 20, 2021Peer-reviewedGenetics