Robert C. Moseley

AutoGater: A Weakly Supervised Neural Network Model to Gate Cells in Flow Cytometric Analyses

AutoGater is a weakly supervised model that identifies viable cells in flow cytometry data using light-scatter channels, without fluorescent stains.

The Parasite Intraerythrocytic Cycle and Human Circadian Cycle are Coupled During Malaria Infection

The paper shows that the host circadian cycle and parasite intraerythrocytic cycle are coupled in P. vivax infections, suggesting potential therapeutic targets.

Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop

This paper introduces DART, a DBTL loop for synthetic genetic circuit design, showing that complex circuits can be more robust and reproducible than simpler ones in budding yeast.

Computational Prediction of Synthetic Circuit Function Across Growth Conditions

The paper develops a computational method to predict synthetic circuit robustness across growth conditions and validates it with experimental results in budding yeast.

Experimental Guidance for Discovering Genetic Networks through Iterative Hypothesis Reduction on Time Series

The paper introduces a computational pipeline to identify core genetic networks from time-series data by iteratively reducing hypotheses, validated on synthetic and yeast cell-cycle data.

Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes

The paper identifies core gene regulatory network components across species by analyzing transcriptome dynamics, revealing shared features in GRNs controlling periodic biological processes.

Highly-Automated, High-Throughput Replication of Yeast-based Logic Circuit Design Assessments

The paper replicates yeast-based logic circuit design assessments using a high-throughput robotic framework, generating more flow cytometry data than the original study.

Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of Plasmodium falciparum

This study identifies transcriptomic changes in Plasmodium falciparum in HbAS red blood cells, showing altered protein export and stress response mechanisms that may contribute to malaria protection.