Author

Joseph W. Saelens

Duke UniversityORCID 0000-0002-6263-7950Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Mahamadou DiakitéiD· 2 shared Steve M. TayloriD· 2 shared Alexander W. MachariaiD· 1 shared Anna E. JeffreysiD· 1 shared Carolyne NdilaiD· 1 shared Christina HubbartiD· 1 shared Christopher M. Reardon· 1 shared Cristina V. ArianiiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Mahamadou DiakitéORCID

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3 papers

Recent·Most cited

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation

Geneva N. Kwaku, Kirstine Nolling Jensen, Patricia Simaku, Daniel J. Floyd, Joseph W. Saelens, Christopher M. Reardon, Rebecca Ward, Kyle J. Basham, Olivia W. Hepworth, Tammy D. Vyas, Daniel Zamith‐Miranda, Joshua Daniel Nosanchuk, Jatin M. Vyas, Hannah E. Brown

This study shows that fungal extracellular vesicles induce species-specific immunomodulation in macrophages through endocytosis-dependent mechanisms, with varying cytokine responses and immune signaling.

PLoS Pathogens · May 30, 2025Peer-reviewedMicrobiology

The protective effect of sickle cell haemoglobin against severe malaria depends on parasite genotype

Gavin Band, Ellen Miranda Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, , Dominic P. Kwiatkowski

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

Nature · Dec 9, 2021Peer-reviewedGenetics

Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of Plasmodium falciparum

Joseph W. Saelens, Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa S Konate, Seidina A. S. Diakité, Karim Traoré, Natalie Vance, Rick M. Fairhurst, Mahamadou Diakité, Steven B. Haase, Steve M. Taylor

This study identifies transcriptomic changes in Plasmodium falciparum in HbAS red blood cells, showing altered protein export and stress response mechanisms that may contribute to malaria protection.

mSphere · Oct 20, 2021Peer-reviewedGenetics