Author

Rick M. Fairhurst

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:plant (other)· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Chanaki Amaratunga· 2 shared Dominic P. KwiatkowskiiD· 2 shared Mahamadou DiakitéiD· 2 shared Megan R. AnsbroiD· 2 shared Olivo MiottoiD· 2 shared Seila Suon· 2 shared ABDOULAYE A. DJIMDÉiD· 1 shared Abhai K. TripathiiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Chanaki Amaratunga

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Author profile →

5 papers

Recent·Most cited

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

Olivo Miotto, Alfred Amambua‐Ngwa, Lucas Naam-Kayagre Amenga-Etego, Muzamil Mahdi Abdel Hamid, Ishag Adam, Enoch Aninagyei, Tobias Obejum Apinjoh, Gordon A. Awandare, Philip Bejon, Gwladys I Bertin, Marielle Karine Bouyou-Akotet, Antoine Claessens, David J. Conway, Umberto D’Alessandro, Mahamadou Diakité, , Dominic P. Kwiatkowski

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

bioRxiv · Jan 20, 2024 · PreprintGenomics

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

Sachel Mok, Tomas Yeo, Davin Hong, Melanie J. Shears, Leila Saxby Ross, Kurt E. Ward, Satish K. Dhingra, Mariko Kanai, Jessica L. Bridgford, Abhai K. Tripathi, Godfree Mlambo, Anna Y. Burkhard, Megan R. Ansbro, Kate J. Fairhurst, Eva Gil‐Iturbe, , David A. Fidock

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.

Science Advances · Nov 8, 2023Peer-reviewedGenomics

Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of Plasmodium falciparum

Joseph W. Saelens, Jens E. V. Petersen, Elizabeth Freedman, Robert C. Moseley, Drissa S Konate, Seidina A. S. Diakité, Karim Traoré, Natalie Vance, Rick M. Fairhurst, Mahamadou Diakité, Steven B. Haase, Steve M. Taylor

This study identifies transcriptomic changes in Plasmodium falciparum in HbAS red blood cells, showing altered protein export and stress response mechanisms that may contribute to malaria protection.

mSphere · Oct 20, 2021Peer-reviewedGenetics

Analysis of Plasmodium vivax schizont transcriptomes from field isolates reveals heterogeneity of expression of genes involved in host-parasite interactions

Sasha V. Siegel, Lia Chappell, Jessica B. Hostetler, Chanaki Amaratunga, Seila Suon, Ulrike Böhme, Matthew Berriman, Rick M. Fairhurst, Julian C. Rayner

This study analyzes P. vivax schizont transcriptomes from field isolates, revealing gene expression heterogeneity and identifying genes involved in host-parasite interactions.

Scientific Reports · Oct 7, 2020Peer-reviewedGenomics

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Christopher G. Jacob, Megan R. Ansbro, Roberto Amato, Mihir Kekre, Ranitha Vongpromek, Mehul Dhorda, Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Olivo Miotto, Rick M. Fairhurst, Thomas E. Wellems, Dominic P. Kwiatkowski

The paper develops and validates PCR assays to detect plasmepsin 2/3 and pfmdr1 copy number variations in Plasmodium falciparum field isolates, finding increasing plasmepsin 2/3 duplications and loss of pfmdr1 mutations in Cambodia.

Malaria Journal · May 13, 2020Peer-reviewedGenetics