Actin cytoskeletal deregulation, caused by RhoGEF2 overexpression, induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway.
Natasha Fahey-Lozano, Marta Portela, John E. La Marca, Helena E. Richardson
The paper shows that RhoGEF2 overexpression causes actin cytoskeletal deregulation, leading to cell elimination via Ptp10D, Crumbs, and Hippo signaling in Drosophila.
bioRxiv · Apr 26, 2025 · PreprintDevelopmental Biology