Marta Portela

This study shows that DNA replication is not required for early mouse embryo development but is necessary for maintaining heterochromatin organization during zygotic genome activation.

The paper studies regulatory genome evolution in echinoderms, revealing deep conservation of cis-regulatory elements and chromatin organization, suggesting an ancestral regulatory pattern in animal genomes.

This paper shows that parental exposure to light stress reduces offspring brain fitness, accelerating glioblastoma progression in Drosophila.

The paper shows that RhoGEF2 overexpression causes actin cytoskeletal deregulation, leading to cell elimination via Ptp10D, Crumbs, and Hippo signaling in Drosophila.

The paper investigates the role of calcium signaling in anterior-posterior axis formation in the mouse embryo, finding that SERCA inhibition disrupts DVE migration and axial patterning.

This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.

This study shows glioblastoma cells deplete Wnt signaling from neurons, leading to tumor growth and neurodegeneration in Drosophila and human xenograft models.