Author

John E. La Marca

The University of MelbourneORCID 0000-0001-6442-9947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Andrew J. KuehiD· 2 shared Benjamin HaleyiD· 2 shared Christina KoenigiD· 2 shared Jean‐Philippe FortiniD· 2 shared Kristel M. DorighiiD· 2 shared Lauren Whelan· 2 shared Lin TaiiD· 2 shared Marco J. HeroldiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrew J. KuehORCID

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3 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedSep 18, 2026

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts…·Marco J. Herold

This paper introduces Partita, a high-density CRISPRa platform for comprehensive gene activation studies, demonstrating its utility in identifying cancer dependencies and resistance pathways in vitro and in vivo.

DOI 10.1126/sciadv.aec0722

mouseCRISPR screen

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Developmental BiologybioRxivPreprintApr 26, 2025

Actin cytoskeletal deregulation, caused by RhoGEF2 overexpression, induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway.

Natasha Fahey-Lozano, Marta Portela, John E. La Marca, Helena E. Richardson

The paper shows that RhoGEF2 overexpression causes actin cytoskeletal deregulation, leading to cell elimination via Ptp10D, Crumbs, and Hippo signaling in Drosophila.

DOI 10.1101/2025.04.26.650750

Drosophilaexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedJan 30, 2025

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

Wei Jin, Yexuan Deng, John E. La Marca…·Marco J. Herold

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.

4 citations

mouseCRISPR screen

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