A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes
Sarah S. J. Rewell, Ali Shad, Lingjun Chen, Matthew G. Macowan, Erskine Chu, Natasha Gandasasmita, Pablo Miguel Casillas-Espinosa, Jian Li, Terence John O'Brien, Bridgette D. Semple
This study shows that LPS treatment after TBI causes acute neuroinflammation and gut microbiome changes but does not affect long-term outcomes.
Experimental Neurology · Jan 20, 2025Peer-reviewedNeuroscience