Ultrasensitive fitness costs arise from membrane proteome displacement under protein overexpression
Janina Müller, Natawan Gadjisade, S. Andreas Angermayr, Gerrit Ansmann, Tobias Bollenbach
The paper quantifies fitness costs of protein overexpression in E. coli, showing growth collapse due to membrane proteome displacement, not translocation pathway saturation.
Cell Systems · Aug 26, 2026Peer-reviewedSystems Biology