Author

Nathália Freire

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

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Arthur Bandeira de Mello GarciaiD· 1 shared Clévia RossetiD· 1 shared Édina PolettoiD· 1 shared Eduardo Cremonese Filippi‐ChielaiD· 1 shared Guilherme BaldoiD· 1 shared Guilherme Danielski ViolaiD· 1 shared Mariane da Cunha JaegeriD· 1 shared Patrícia Ashton‐ProllaiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperMolecular Biology

Arthur Bandeira de Mello GarciaORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintAug 11, 2026

Metformin modulates autophagy in heterozygous and CRISPR-edited TSC2 primary fibroblasts

Guilherme Danielski Viola, Pedro Ozório Brum, Arthur Bandeira de Mello Garcia…·Clévia Rosset

This study shows that metformin restores autophagy in TSC2 haploinsufficient and CRISPR-edited fibroblasts by blocking mTORC1, suggesting a potential therapeutic strategy for TSC.

DOI 10.64898/2026.08.11.743350

humanexperimental assay

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