Author

Arthur Bandeira de Mello Garcia

Universidade Federal do Rio Grande do SulORCID 0000-0002-9533-9562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Clévia RossetiD· 2 shared Patrícia Ashton‐ProllaiD· 2 shared Cristina Brinckmann Oliveira Netto· 1 shared Édina PolettoiD· 1 shared Eduardo Cremonese Filippi‐ChielaiD· 1 shared Guilherme BaldoiD· 1 shared Guilherme Danielski ViolaiD· 1 shared Larissa Brussa ReisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Clévia RossetORCID

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2 papers

Recent·Most cited

Metformin modulates autophagy in heterozygous and CRISPR-edited TSC2 primary fibroblasts

Guilherme Danielski Viola, Pedro Ozório Brum, Arthur Bandeira de Mello Garcia, Mariane da Cunha Jaeger, Nathália Freire, Eduardo Cremonese Filippi‐Chiela, Guilherme Baldo, Édina Poletto, Patrícia Ashton‐Prolla, Clévia Rosset

This study shows that metformin restores autophagy in TSC2 haploinsufficient and CRISPR-edited fibroblasts by blocking mTORC1, suggesting a potential therapeutic strategy for TSC.

bioRxiv · Aug 11, 2026 · PreprintMolecular Biology

TSC1 mRNA processing alterations in tuberous sclerosis complex (TSC) patients with negative or inconclusive genetic testing results

Arthur Bandeira de Mello Garcia, Taís da Silveira Fischer, Maria Clara de Freitas Pinho, Lucas Fernandes Jatai, Patrícia Santos da Silva, Tiago Finger Andreis, Larissa Brussa Reis, Cristina Brinckmann Oliveira Netto, Patrícia Ashton‐Prolla, Clévia Rosset

This study identifies mRNA processing errors in TSC patients with negative or inconclusive genetic tests using cDNA analysis, reclassifying a variant of uncertain significance as pathogenic.

medRxiv · Jan 30, 2025 · PreprintGenetic & Genomic Medicine