A complex CTCF binding code defines TAD boundary structure and function
Li‐Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer
The paper reveals that CTCF binding at TAD boundaries is modular and clustered, challenging existing models of loop extrusion blocking and highlighting a complex code for TAD structure and function.
Nature Communications · Sep 12, 2023Peer-reviewedGenetics