Eric F. Joyce

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

The paper shows that RNA enhances condensate formation by ENL mutants, promoting oncogenic transcription and leukemogenesis in mouse models.

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The paper identifies hnRNPK as a key regulator of LAD positioning and reveals two distinct LAD classes based on epigenetic marks.

SWING regions prime chromatin for nuclear speckle mediated gene regulation

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

B cell stimulation changes the structure and higher-order organization of the inactive X chromosome

This study investigates how B cell stimulation affects the structure and organization of the inactive X chromosome, revealing dynamic changes in TAD boundaries and Xi compaction.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis

The paper shows that genome organization influences NPC formation and differentiation in Drosophila oogenesis by regulating gene silencing and Nup activation.

A complex CTCF binding code defines TAD boundary structure and function

The paper reveals that CTCF binding at TAD boundaries is modular and clustered, challenging existing models of loop extrusion blocking and highlighting a complex code for TAD structure and function.

CTCF/cohesin organize the ground state of chromatin-nuclear speckle association

This study identifies CTCF and cohesin as essential for chromatin-nuclear speckle association, showing their role in gene inducibility and relevance to disease.

High-throughput Oligopaint screen identifies druggable regulators of genome folding

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

An atlas of lamina-associated chromatin across twelve human cell types revealsan intermediate chromatin subtype

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

Remodeling and compaction of the inactive X is regulated by Xist during female B cell activation

This study shows that Xist regulates Xi compaction and TAD boundaries in B cells, impacting XCI maintenance and X-linked gene expression.

NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

This study shows that NIPBL and WAPL regulate cohesin activity to control chromatin folding and gene expression, with their relative levels determining transcriptional outcomes.

CTCF blocks anti-sense transcription initiation at divergent gene promoters

The paper shows CTCF suppresses antisense transcription at divergent promoters without affecting sense transcription, using a combination of genetic and molecular techniques.

The genome-wide, multi-layered architecture of chromosome pairing in early Drosophila embryos

A haplotype-resolved Hi-C approach reveals structured homolog pairing in early Drosophila embryos, correlated with Zelda-mediated chromatin accessibility.