Inositol Polyphosphate-4-Phosphatase Type II promotes gemcitabine resistance in pancreatic ductal adenocarcinoma cells via lysosomal exocytosis
Ché M.P. Melo, Candaice A. Newell, Golam T. Saffi, Nathan Ng, Cuyler Yu, Cheng An Wang, Lydia To, Jonathan Tak-Sum Chow, Leonardo Salmena
This study shows INPP4B promotes gemcitabine resistance in PDAC by enhancing lysosomal exocytosis, which can be reversed by lysosome-targeting drugs.
bioRxiv · Aug 24, 2026 · PreprintCancer Biology