Author

Jonathan Tak-Sum Chow

University of TorontoORCID 0000-0002-6783-5032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Leonardo SalmenaiD· 3 shared Daniel K.C. Lee· 2 shared Martino GabraiD· 2 shared Ayeisha DesjardinsiD· 1 shared Byeong Yeop Lee· 1 shared Candaice A. Newell· 1 shared Ché M.P. MeloiD· 1 shared Cheng An Wang· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Leonardo SalmenaORCID

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3 papers

Recent·Most cited

Inositol Polyphosphate-4-Phosphatase Type II promotes gemcitabine resistance in pancreatic ductal adenocarcinoma cells via lysosomal exocytosis

Ché M.P. Melo, Candaice A. Newell, Golam T. Saffi, Nathan Ng, Cuyler Yu, Cheng An Wang, Lydia To, Jonathan Tak-Sum Chow, Leonardo Salmena

This study shows INPP4B promotes gemcitabine resistance in PDAC by enhancing lysosomal exocytosis, which can be reversed by lysosome-targeting drugs.

bioRxiv · Aug 24, 2026 · PreprintCancer Biology

A microRNA CRISPR screen reveals miR-483-3p as an apoptotic regulator in prostate cancer

Jonathan Tak-Sum Chow, Ayeisha Desjardins, Daniel K.C. Lee, Iulia A Grigore, Linda Lee, Norman J. Fu, Stephanie Chau, Byeong Yeop Lee, Martino Gabra, Leonardo Salmena

The paper uses a CRISPR-based screen to identify miR-483-3p as a key apoptotic regulator in prostate cancer, showing its role in cell survival and potential as a therapeutic target.

Cell Death and Disease · Oct 24, 2025Peer-reviewedCancer Biology

Phosphoinositide-focused CRISPR screen identifies novel genetic vulnerabilities in PDAC and AML cells

Daniel K.C. Lee, Ryan Loke, Jonathan Tak-Sum Chow, Martino Gabra, Leonardo Salmena

The paper uses a PI-focused CRISPR screen to identify essential genes and regulators in PDAC and AML cells, revealing novel therapeutic targets and demonstrating the efficiency of focused libraries.

bioRxiv · Sep 9, 2024 · PreprintCancer Biology