Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2
Jordan Anderson-Daniels, Meghan V. Diefenbacher, Boyd L. Yount, Rita M. Meganck, Longping V. Tse, Kaitlyn N. Burke, Hector A. Miranda, D. Trevor Scobey, Xiaotao Lu, Laura J. Stevens, Kenneth H. Dinnon, Nathaniel S. Chapman, Camryn Pajon, John M. Powers, Cameron Nguyen, , Timothy Patrick Sheahan
This study shows that SARS-CoV-2 with impaired nsp14-exonuclease activity has reduced replication, fitness, and pathogenesis, but remains viable in some conditions.
mBio · May 6, 2026Peer-reviewedMicrobiology