MicrobiologymBioPeer-reviewed
Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2
Jordan Anderson-Daniels, Meghan V. Diefenbacher, Boyd L. Yount…·Timothy Patrick Sheahan
This study shows that SARS-CoV-2 with impaired nsp14-exonuclease activity has reduced replication, fitness, and pathogenesis, but remains viable in some conditions.