Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Yuki Makino, Kimal Rajapakshe, Benson Chellakkan Selvanesan, Takashi Okumura, Kenjiro Date, Prasanta Dutta, Lotfi Abou‐Elkacem, Akiko Sagara, Jimin Min, Marta Sans, Nathaniel Yee, Megan J. Siemann, José S. Enriquez, Paytience Smith, Pratip K. Bhattacharya, , Fredrik I. Thege
This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.
Gut · Sep 13, 2024Peer-reviewedCancer Biology