Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin
Nithin Sam Ravi, Beeke Wienert, Stacia K. Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T. Vu, K. Manjunatha Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, , Kumarasamypet Murugesan Mohankumar
This study uses CRISPR base editing to identify novel mutations in the HBG promoter that increase fetal hemoglobin expression without harmful effects.
eLife · Feb 11, 2022Peer-reviewedGenomics