Mitofusin agonists improve the long-term repopulating activity of human cord blood HSCs after ex vivo culture
Alyssa Biondo, Gabriela de Toledo Passos Candelaria, Daniel K. Jin, Emily Pei-Ying Lin, Daniel J. McLaughlin, Jessica Freedman, Zhaolun Liang, Katherine J. Leong, Ya-Ju Chang, Zhiran Geng, Nazia Nayeem, Zachary Leontiou, Emma Laquinta, Christopher D. Hillyer, Hans‐Willem Snoeck, Larry L. Luchsinger
The paper shows mitofusin agonists enhance long-term repopulating activity of human cord blood HSCs in ex vivo culture without changing total nucleated cells or phenotypic HSCs.
bioRxiv · Oct 27, 2025 · PreprintCell Biology