The paper shows mitofusin agonists enhance long-term repopulating activity of human cord blood HSCs in ex vivo culture without changing total nucleated cells or phenotypic HSCs.

bioRxiv · Oct 27, 2025 · PreprintCell Biology

The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies

Hsin‐Chou Yang, Pui–Yan Kwok, Ling-Hui Li, Yi-Min Liu, Yuh‐Jyh Jong, Kang‐Yun Lee, Da-Wei Wang, Ming-Fang Tsai, Jenn-Hwai Yang, Chien-Hsiun Chen, Erh‐Chan Yeh, Chun-Yu Wei, Cathy S.J. Fann, Yen‐Tsung Huang, Chia-Wei Chen, , Ming‐Chin Yu

The Taiwan Precision Medicine Initiative (TPMI) recruits a large cohort for genetic and electronic medical record studies to advance precision medicine.

Nature · Oct 15, 2025Peer-reviewedGenetics

Outer membrane vesicles from Bacteroides fragilis contain coding and non-coding small RNA species that modulate inflammatory signaling in intestinal epithelial cells.

Aadil Sheikh, Colin Scano, Julia Xu, Tolulope Ojo, Jessica M. Conforti, Kayla L. Haberman, Bryan King, Alysia S. Martinez, Michelle Pujol, Juli Watkins, James Lotter, Emily Pei-Ying Lin, Bernd Zechmann, Amanda Sevcik, Christie Maria Sayes, , K. Leigh Greathouse

This study identifies coding and non-coding small RNAs in Bacteroides fragilis outer membrane vesicles that modulate inflammatory responses in intestinal epithelial cells, with ETBF OMVs showing immunosuppressive effects.

bioRxiv · Jun 25, 2025 · PreprintMolecular Biology