Paired CRISPR screens to map gene regulation in cis and trans
Xinhe Xue, Zoran Z. Gajic, Christina M. Caragine, Mateusz Legut, Conor R. Walker, James Y.S. Kim, Xiao Wang, Rachel Yan, Hans‐Hermann Wessels, Congyi Lu, Neil Bapodra, Gamze Gürsoy, Neville E. Sanjana
The paper uses paired CRISPR screens to identify cis- and trans-regulatory elements controlling PD-L1 expression in PDAC cells and links them to clinical outcomes.
bioRxiv · Nov 27, 2024 · PreprintGenomics