Author

Rachel Yan

New York Genome CenterORCID 0000-0002-6718-142XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Neville E. SanjanaiD· 2 shared Adam C. ResnickiD· 1 shared Akash Sookdeo· 1 shared Bo ZhangiD· 1 shared Christina M. CaragineiD· 1 shared Congyi LuiD· 1 shared Conor R. WalkeriD· 1 shared Daniel P. MilleriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenomics

Neville E. SanjanaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Machine learning-predicted chromatin organization landscape across pediatric tumors

Ketrin Gjoni, Shu Zhang, Rachel Yan, Bo Zhang, Daniel P. Miller, Jeffrey Peter Greenfield, Adam C. Resnick, Nadia Dahmane, Katherine S. Pollard

The paper uses a convolutional neural network to predict chromatin organization disruptions caused by somatic structural variants in pediatric tumors, identifying high-impact SVs and regions associated with cancer.

Scientific Reports · Mar 28, 2026Peer-reviewedGenomics

Transcriptome-wide profiling of alternative splicing regulators with CRISPore-seq

Simon Müller, Nathanael Andrews, Rachel Yan, Akash Sookdeo, Wells H. Burrell, Xiaoguang Dai, Priyesh Rughani, Zharko Daniloski, Sissel Juul, Neville E. Sanjana

CRISPore-seq combines CRISPR perturbations with long-read transcriptomics to detect alternative splicing changes, revealing that exon skipping is common and linked to RNA-binding protein perturbations.

bioRxiv · Nov 25, 2025 · PreprintGenomics

Paired CRISPR screens to map gene regulation in cis and trans

Xinhe Xue, Zoran Z. Gajic, Christina M. Caragine, Mateusz Legut, Conor R. Walker, James Y.S. Kim, Xiao Wang, Rachel Yan, Hans‐Hermann Wessels, Congyi Lu, Neil Bapodra, Gamze Gürsoy, Neville E. Sanjana

The paper uses paired CRISPR screens to identify cis- and trans-regulatory elements controlling PD-L1 expression in PDAC cells and links them to clinical outcomes.

bioRxiv · Nov 27, 2024 · PreprintGenomics