Zoran Z. Gajic

Functional border-associated macrophages limit Alzheimer's Disease progression

This study shows that border-associated macrophages (BAM) are critical in limiting Alzheimer's Disease progression by clearing beta-amyloid, and their loss accelerates disease pathology.

Paired CRISPR screens to map gene regulation in cis and trans

The paper uses paired CRISPR screens to identify cis- and trans-regulatory elements controlling PD-L1 expression in PDAC cells and links them to clinical outcomes.

Target-dependent siRNA suppression distinguishes self from non-self endogenous siRNAs in C. elegans germline

The paper shows that siRNA suppression in C. elegans germline depends on target genes, distinguishing self from non-self siRNAs.

Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

The paper identifies three novel complex structural variation patterns in cancer genomes using genome graph analysis across 2,833 tumor WGS.

Caenorhabditis elegans heterochromatin factor SET-32 plays an essential role in transgenerational establishment of nuclear RNAi-mediated epigenetic silencing

This study identifies SET-32 as essential for the transgenerational establishment of nuclear RNAi-mediated silencing in C. elegans, showing it is dispensable for maintenance once silencing is established.