Single Molecule Visualization of Cardiac Myosin-Binding Protein C N-terminal Fragments Interacting with Thin Filaments: Mechanisms of Calcium Sensitization
Alessio V. Inchingolo, Samantha Beck Previs, Michael J. Previs, David M. Warshaw, Neil M. Kad
This study uses single-molecule microscopy to show that the C0C3 fragment of cMyBP-C enhances myosin binding at low calcium but blocks it at high calcium, suggesting a role in calcium sensitization.
bioRxiv · Sep 23, 2018 · PreprintBiophysics