Michael J. Previs

This paper introduces a framework to model haploinsufficiency-mediated human disorders by modulating gene dosage through splicing, demonstrating its application in creating accurate animal models for cardiomyopathies.

This study determines the structure of Plasmodium falciparum MyoB, shows it is a slow motor optimized for force generation during invasion, and identifies its light chain as shared with MyoA.

This study shows that developmental temperature alters muscle mechanics in larval zebrafish to counteract environmental temperature effects on tail muscle function.

This study investigates the functional role of MyBP-H in developing vertebrate fast-twitch skeletal muscle using zebrafish and rat models, revealing its involvement in myofilament lattice compression and contractility regulation.

The paper shows that daily vocal exercise is necessary for songbirds to maintain peak vocal muscle performance and that this affects song quality and mate preference.

This study uses single-molecule microscopy to show that the C0C3 fragment of cMyBP-C enhances myosin binding at low calcium but blocks it at high calcium, suggesting a role in calcium sensitization.

This study identifies an essential light chain for Plasmodium falciparum class XIV myosin that enhances actin motility speed when expressed with the heavy chain and known light chain.