Neil M. Kad

This study investigates the R403Q mutation in beta-myosin heavy chain using porcine and human stem cell models, revealing altered contractile properties and mechanisms of hypercontractility and impaired relaxation.

The paper measures how mavacamten and deoxyATP affect the SRX/DRX ratio in porcine cardiac myofibrils using a fluorescence imaging approach.

This study characterizes mitotic chromosome mechanics and shows the mitotic chromosome periphery (MCP) provides force-damping properties and structural constraints.

This study uses single molecule imaging to analyze how phosphorylation affects myosin activity and cardiac reserve in porcine sarcomeres, identifying distinct kinetic states and their modulation by phosphorylation.

This paper shows Aficamten inhibits cardiac myosin ATPase without changing thick filament structure, unlike Mavacamten, leading to similar force reduction but different kinetic effects.

SMADNE characterizes DNA-binding protein dynamics using single-molecule analysis from nuclear extracts, revealing binding lifetimes, diffusion, and complex assembly kinetics.