David M. Warshaw

The Phosphorylation State of Melanophilin, a Myosin Va Adapter Protein, Biases the Tug-of-War Between Myosin Va and Kinesin-1 on Liposomes at Actin-Microtubule Intersections In Vitro

This study shows phosphorylated melanophilin biases liposome exit from actin-microtubule intersections toward actin, while dephosphorylated melanophilin biases exit toward microtubules.

Thermal acclimation and resultant developmental adaptation offsets environmental temperature effects on tail muscle mechanics in larval zebrafish

This study shows that developmental temperature alters muscle mechanics in larval zebrafish to counteract environmental temperature effects on tail muscle function.

Identification of UCB-9721 as a potent inhibitor of MyoA, the essential class XIV myosin motor of apicomplexan parasites

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

Kinesin-1 Autoinhibition Tunes Cargo Transport by Motor Ensembles

This study investigates how kinesin-1 autoinhibition affects cargo transport through 3D microtubule intersections, showing that autoinhibited motors reduce MT engagement and alter directional outcomes.

Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

This study investigates the functional role of MyBP-H in developing vertebrate fast-twitch skeletal muscle using zebrafish and rat models, revealing its involvement in myofilament lattice compression and contractility regulation.

Tail Length and E525K Dilated Cardiomyopathy Mutant Alter Human β-Cardiac Myosin Super-Relaxed State

This paper examines how the E525K mutation in human β-cardiac myosin affects its super-relaxed state and contractility in dilated cardiomyopathy.

Modeling myosin Va liposome transport through actin filament networks reveals a percolation threshold that modulates transport properties

The paper models myosin Va liposome transport through actin networks, finding a percolation threshold that determines transport behavior based on actin density and cargo size.

Mutations in MYLPF cause a novel segmental amyoplasia that manifests as distal arthrogryposis

The paper identifies mutations in MYLPF causing segmental amyoplasia with distal arthrogryposis, showing both dominant and recessive inheritance patterns and linking MYLPF impairment to muscle degeneration.

Single Molecule Visualization of Cardiac Myosin-Binding Protein C N-terminal Fragments Interacting with Thin Filaments: Mechanisms of Calcium Sensitization

This study uses single-molecule microscopy to show that the C0C3 fragment of cMyBP-C enhances myosin binding at low calcium but blocks it at high calcium, suggesting a role in calcium sensitization.