Apoptotic Cells Promote Tim4+ Macrophage Differentiation Through Direct and Indirect Signaling Pathways
Bryan S. Manning, Linna Zhu, Brennah Murphy, Marlaine Maged Hosny Soliman, Chunlei Shao, Nesteene Param, Taito Miyamoto, Rahul Shinde, Martin P Carroll
This study shows that apoptotic cells promote Tim4+ macrophage differentiation through both direct and indirect signaling pathways involving efferocytosis and IL-4R-STAT6 signaling.
bioRxiv · Oct 13, 2026 · PreprintImmunology