Author

Brennah Murphy

The Wistar InstituteORCID 0000-0003-3698-6513Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bryan S. ManningiD· 3 shared Taito MiyamotoiD· 3 shared Andrew V. KossenkoviD· 2 shared Kohei HamadaiD· 2 shared Yulia NefedovaiD· 2 shared Alessio UgoliniiD· 1 shared Chunlei ShaoiD· 1 shared Daniel T. ClaiborneiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Bryan S. ManningORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 13, 2026

Apoptotic Cells Promote Tim4+ Macrophage Differentiation Through Direct and Indirect Signaling Pathways

Bryan S. Manning, Linna Zhu, Brennah Murphy…·Martin P Carroll

This study shows that apoptotic cells promote Tim4+ macrophage differentiation through both direct and indirect signaling pathways involving efferocytosis and IL-4R-STAT6 signaling.

DOI 10.64898/2026.10.12.758552

mousebulk RNA-seq

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ImmunologybioRxivPreprintSep 21, 2025

Chemotherapy Induces an IL1β-dependent Neutrophil Recruitment that Promotes Chemoresistance in Metastatic Ovarian Cancer

Taito Miyamoto, Yujie Ye, Bryan S. Manning…·Nan Zhang

This study shows chemotherapy induces IL1β-dependent neutrophil recruitment, promoting chemoresistance in metastatic ovarian cancer through NETs and immune modulation.

DOI 10.1101/2025.09.21.677600

mousehuman

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ImmunologyThe Journal of Experimental MedicinePeer-reviewedOct 16, 2024

Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan S. Manning…·Nan Zhang

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

19 citations

mouseexperimental assay

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