BioinformaticsbioRxivPreprint
Computational Engineering of a Therapeutic Antibody to Inhibit Multiple Mutants of HER2 Without Compromising Inhibition of the Canonical HER2
Sapir Peled, Julia Guez-Haddad, Nevet Zur Biton…·Yanay Ofran
The paper designs a multi-specific antibody that retains Pertuzumab's function while inhibiting multiple HER2 mutants, showing effectiveness against S310Y, S310F, and wild-type HER2.
DOI 10.1101/2023.07.21.550003