Regioselectively Acetylated Silybin Derivatives and their Cytotoxic Activity in Liver Cancer Cells
Trần Văn Chiến, Thao Thi Phuong Tran, Nguyễn Thế Anh, Trần Văn Lộc, Michelle Dawn Garrett, Nguyen Thi Nga, Do Thi Thao, Christopher J. Serpell, Tran Van Sung
This study synthesizes and tests six silybin derivatives, finding one shows 12-fold stronger cytotoxicity against liver cancer cells than silybin itself.
bioRxiv · Feb 13, 2025 · PreprintPharmacology & Toxicology