Minor spliceosome inactivation in the developing mouse cortex causes self-amplifying radial glial cell death and microcephaly.
Marybeth Baumgartner, Anouk M. Olthof, Gabriela S. Aquino, Katery C. Hyatt, Christopher Lemoine, Kyle D. Drake, Nikita Sturrock, Nhut Nguyen, Sahar Al Seesi, Rahul Kanadia
The paper investigates the role of the minor spliceosome in cortical development by ablating Rnu11 in mice, revealing microcephaly due to radial glial cell death.
Development · Aug 9, 2018Peer-reviewedDevelopmental Biology