Anouk M. Olthof

The paper shows that reducing RNA polymerase II levels disrupts transcriptional homeostasis through organized gene expression changes and feedback loops.

The paper classifies introns into five types, identifies their evolutionary patterns, and shows that minor introns are stress-responsive in fish and plants.

The paper identifies MIG-encoded proteins as potential pan-viral drug targets, showing that repurposed anti-cancer drugs target these proteins.

The paper shows that minor and major spliceosomes interact to regulate alternative splicing around minor introns, linking this interaction to disease pathogenesis.

The paper investigates the role of the minor spliceosome in cortical development by ablating Rnu11 in mice, revealing microcephaly due to radial glial cell death.