Development and validation of highly selective monoclonal antibodies for the detection of huntingtin neoepitopes
Antonino Missineo, Licia Tomei, Nadine Alaimo, Paola Martufi, Marta Zavattieri, Valeria Colicchia, Cristina Cariulo, Valentina Fodale, Jacqueline Seguin, Candi M. Esquina, Nian Huang, Hsuan-Yi Wu, James B. Pace, Jemima M Phillips, Christian Landles, , Elizabeth M. Doherty
This paper develops and validates recombinant monoclonal antibodies that selectively detect specific huntingtin neoepitopes, addressing variability in existing antibodies and enabling new research into huntingtin fragment cleavage mechanisms.
bioRxiv · Aug 26, 2026 · PreprintNeuroscience