Ignacio Muñoz-Sanjuán

This study uses longitudinal MRI to analyze brain volume changes in zQ175DN mice, finding early striatal atrophy and later cortical and corpus callosum reductions similar to human HD.

This paper develops and validates recombinant monoclonal antibodies that selectively detect specific huntingtin neoepitopes, addressing variability in existing antibodies and enabling new research into huntingtin fragment cleavage mechanisms.

The paper develops an ultrasensitive immunoassay to detect S421 phosphorylation of huntingtin in HD models and nonhuman primate CSF, linking it to disease progression and identifying PRKACA as a kinase involved.

This paper evaluates [18F]CHDI-650, a novel PET radiotracer, for imaging mutant huntingtin aggregates in HD mouse models, showing genotype discrimination at 3 and 9 months.

The paper investigates changes in resting-state co-activation patterns in a Huntington's disease mouse model and finds they predict disease states with high accuracy.

This study uses resting-state fMRI to track longitudinal changes in brain network connectivity in a mouse model of Huntington's disease, revealing age-related alterations in cortical and subcortical networks.

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

This paper develops a PET radioligand to visualize mutant huntingtin levels in the brain and assess therapeutic interventions in Huntington's disease.